Publications

Refereed Publications:

2025

• Hamilton, T. J., Cheung, K., Hudson, J., Szaszkiewicz, J., Ingraham, E., Krook, J., Johnson, A., Franczak, B., McAdam, S., & Brauner, C. J. (2025). Embryological incubation temperature modulates behaviour in larval white sturgeon (Acispencer Transmontanus). Journal of Thermal Biology, 127, 104069. https://doi.org/10.1016/j.jtherbio.2025.104069

• Amin, M. R., Khara, L., Szaszkiewicz, J., Kim, A. M., Hamilton, T. J., & Ali, D. W. (2025). Brief exposure to (-) THC affects zebrafish embryonic locomotion with effects that persist into the next generation. Scientific Reports, 15(1). https://doi.org/10.1038/s41598-024-82353-3

2024

• Hagen E*, Zhang Y, Hamilton TJ. (2024). From Colours to Cravings: Exploring Conditioned Colour Preference to Ethanol in Zebrafish. Pharmacol Biochem Behav. https://dx.doi.org/10.2139/ssrn.4885408

  
  
  

• Johnson AL*, Hurd PL, Hamilton TJ. Sex, drugs, and zebrafish: Acute exposure to anxiety-modulating compounds in a modified novel tank dive test. (2024) Pharmacol Biochem Behav. 243:173841. doi: 10.1016/j.pbb.2024.173841

  
  

  
  

• Hagen E*, Schalomon M, Zhang Y, Hamilton TJ. (2024). Repeated microdoses of LSD do not alter anxiety or boldness in Zebrafish. Scientific reports. https://doi.org/10.1038/s41598-024-54676-8

  
  

• Scatterty K*, Hamilton TJ. (2024). β-Carboline (FG-7142) Modulates fear but not anxiety-like behaviour in zebrafish. Scientific Reports. doi.org/10.1038/s41598-023-51072-6

2023

• Johnson A*, Verbitsky R*, Hudson J*, Dean R*, Hamilton TJ. (2023). Cannabinoid Type-2 receptors modulate terpene induced anxiety-reduction in zebrafish. Biomedicine and Pharmacotherapy. doi.org/10.1016/j.biopha.2023.115760

• Hagen, E. V., Zhang, Y., & Hamilton, T. J. (2023). Innate colour preference in zebrafish (danio rerio). MethodsX, 11, 102342. https://doi.org/10.1016/j.mex.2023.102342

  
  

• Hamilton, T. J., Tresguerres, M., Kwan, G. T., Szaskiewicz, J., Franczak, B., Cyronak, T., Andersson, A. J., & Kline, D. I. (2023). Effects of ocean acidification on dopamine-mediated behavioral responses of a coral reef damselfish. Science of The Total Environment, 877, 162860. https://doi.org/10.1016/j.scitotenv.2023.162860

  
  
  

• Johnson, A., Loh, E., Verbitsky, R., Slessor, J., Franczak, B. C., Schalomon, M., & Hamilton, T. J. (2023). Examining behavioural test sensitivity and locomotor proxies of anxiety-like behaviour in zebrafish. Scientific Reports, 13(1), 3768. https://doi.org/10.1038/s41598-023-29668-9

  
  
  

• Chaput, S.-L., Burggren, W. W., Hurd, P. L., & Hamilton, T. J. (2023). Zebrafish (danio rerio) shoaling in light and dark conditions involves a complex interplay between vision and lateral line. Behavioural Brain Research, 439, 114228. https://doi.org/10.1016/j.bbr.2022.114228

  
  

• Scatterty, K. R., Pitman, T., Eckersley, T., Schmaltz, R., & Hamilton, T. J. (2023). Zebrafish aversion to infrasound in an open field test. Frontiers in Behavioral Neuroscience, 16. https://doi.org/10.3389/fnbeh.2022.1019368

  
  

2022

• Johnson, A., Stewart, A., El-Hakim, I., & Hamilton T. J. (2022). Effects of super-class cannabis terpenes beta-caryophyllene and alpha-pinene on zebrafish behavioural biomarkers. Scientific Reports, 12(1), 1725 . https://doi.org/10.1038/s41598-022-21552-2

  
  

2021

• Szaszkiewicz, J., Leigh, S., & Hamilton, T. J. (2021). Robust behavioural effects in response to acute, but not repeated, terpene administration in Zebrafish (Danio rerio). Scientific reports, 11(1), 19214.

• Hamilton, T. J., Szaszkiewicz, J., Krook, J., Richards, J. G., Stiller, K., & Brauner, C. J. (2021). Continuous light (relative to a 12:12 photoperiod) has no effect on anxiety-like behaviour, boldness, and locomotion in coho salmon (Oncorhynchus kisutch) post-smolts in recirculating aquaculture systems at a salinity of either 2.5 or 10 ppt. Comparative biochemistry and physiology. Part A, Molecular & integrative physiology, 263.

• Hamilton, T. J., Szaszkiewicz, J., Krook, J., & Burggren, W. (2021). Analysis of the potential behavioral impact of methanol when used as a solvent: Dataset from zebrafish (Danio rerio) behavioral research. Data in brief, 36, 107018.

  
  
  
  

• Hamilton, T. J., Radke, N. H., Bajwa, J., Chaput, S., & Tresguerres, M. (2021). The dose makes the poison: Non-linear behavioural response to CO2-induced aquatic acidification in zebrafish (Danio rerio). Science of The Total Environment, 778, 146320. doi:10.1016/j.scitotenv.2021.146320

• Hamilton, T. J., Krook, J., Szaszkiewicz, J., & Burggren, W. (2021). Shoaling, boldness, anxiety-like behavior and locomotion in zebrafish (danio rerio) are altered by acute benzo[a]pyrene exposure. Science of The Total Environment, 774, 145702. doi:10.1016/j.scitotenv.2021.145702
  
  
  
  

• Dean R, Hurst Radke N, Velupillai N, Franczak BC, Hamilton TJ. 2021. Vision of conspecifics decreases the effectiveness of ethanol on zebrafish behaviour. PeerJ 9:e10566 https://doi.org/10.7717/peerj.10566
  
  
  
  

2020

• Dean, R., Duperreault, E., Newton, D., Krook, J., Ingraham, E., Gallup, J., Franczak, B., Hamilton TJ. (2020). Opposing effects of acute and repeated nicotine exposure on boldness in zebrafish. Sci Rep 10, 8570 (2020).

  
  
  

2019

• Glover C, Newton D, Bajwa J, Goss G, Hamilton TJ. (2019). Behavioural responses of the hagfish Eptatretus stoutii to nutrient and noxious stimuli. Scientific Reports. 9. 10.1038/s41598-019-49863-x. 

• Reardon A, Karathra J, Ribbenstedt A, Benskin J, MacDonald A, Kinniburgh D, Hamilton TJ, Fouad K, Martin J. (2019). Neurodevelopmental and Metabolomic Responses from Prenatal Co-Exposure to Perfluorooctane Sulfonate (PFOS) and Methylmercury (MeHg) in Sprague-Dawley Rats. Chemical Research in Toxicology. 32. 10.1021/acs.chemrestox.9b00192.

  
  
  

• Scavuzzo C, Leblancq M, Nargang F, Lemieux H, Hamilton TJ, Dickson C. (2019). The amnestic agent anisomycin disrupts intrinsic membrane properties of hippocampal neurons via a loss of cellular energetics. Journal of Neurophysiology. 122. 10.1152/jn.00370.2019.

  
  
  

• Hope B, Hamilton TJ, Hurd P. (2019). The submerged plus maze as an assay for studying anxiety-like behaviour in fish. MethodsX. 6. 10.1016/j.mex.2019.07.002. 

• Krook J, Duperreault E, Newton D, Ross M, Hamilton TJ. (2019). Repeated ethanol exposure increases anxiety-like behaviour in zebrafish during withdrawal. PeerJ. 7. e6551. 10.7717/peerj.6551. 

  
  
  

2018

• Hope B, Hamilton TJ, Hurd P. (2018). Submerged plus maze: A novel test for studying anxiety-like behaviour in fish. Behavioural Brain Research. 362. 10.1016/j.bbr.2018.12.012.

  
  
  

• Hamilton TJ, Kline DI, Tresguerres M. (2018) Shoaling behaviour is differentially altered by ethanol and dopamine D1 receptor modulators in tropical marine forage fish. Canadian Journal of Fisheries and Aquatic Sciences. 75(7), 999–1004. doi: 10.1139/cjfas-2018-0084

• Leighton PLA, Nadolski NJ, Morrill A, Hamilton TJ, Allison WT. (2018) An ancient conserved role for prion protein in learning and memory. Biology Open. 7(1).

2017

• Hamilton TJ, Morrill A, Lucas K, Gallup J, Harris M, Healey M, Pitman T, Schalomon M, Digweed S, Tresguerres M. (2017) Establishing zebrafish as a model to study the anxiolytic effects of scopolamine. Scientific Reports. 7(1):15081. doi: 10.1038/s41598-017-15374-w

• Blewett TA, Newton D, Flynn SL, Alessi DS, Goss GG, Hamilton TJ. (2017) Cadmium bioaccumulates after acute exposure but has no effect on locomotion or shelter-seeking behaviour in the invasive green shore crab (Carcinus maenas). Conservation Physiology. 5(1). cox057.

• Rimstad L, Holcombe A, Pope A, Hamilton TJ, Schalomon M. (2017) Preferences for Achromatic Horizontal, Vertical, and Square Patterns in Zebrafish (Danio rerio). PeerJ. 5:e3748

• Hamilton TJ, Tresguerres M, Kline D (2017) Dopamine D1 receptor activation leads to object recognition memory in a coral reef fish. Biology Letters. 13(7), 20170183.

• Kwan G, Hamilton TJ, Tresguerres M. (2017) Ocean acidification-like conditions do not affect individual or group behaviour of the temperate damselfish (Chromis punctipinnis). Royal Society Open Science.170283.

• Tresguerres M, Hamilton TJ. (2017) Acid–base physiology, neurobiology and behaviour in relation to aquatic CO2-induced acidification. Journal of Experimental Biology. 220 (12), 2136-2148.

• Johnson A, Hamilton TJ. (2017) Modafinil decreases anxiety-like behaviour in zebrafish. PeerJ 5:e2994. doi: 10.7717/peerj.2994

 2016

• Ingraham E, Anderson N, Hurd P, Hamilton TJ (2016) Twelve-Day Reinforcement-Based Memory Retention in African cichlids (Labidochromis caeruleus) Frontiers in Behavioural Neuroscience. doi: 10.3389/fnbeh.2016.00157

• Hamilton TJ, Myggland A, Duperreault E, May Z, Gallup J, Powell RA, Schalomon M, Digweed S. (2016) Episodic-like memory in zebrafish. Animal Cognition. 1-9. doi: 10.1007/s10071-016-1014-1

• Hamilton TJ, Kwan G, Gallup J, Tresguerres M. (2016) Acute fluoxetine exposure alters crab anxiety-like behaviour, but not aggressiveness. Scientific Reports. 6: 19850. doi:10.1038/srep19850

• May Z, Morrill A, Holcombe A, Johnston T, Gallup J, Fouad K, Schalomon M, Hamilton TJ. (2016) Object recognition memory in zebrafish. Behavioural Brain Research. 296: 199-210. doi:10.1016/j.bbr.2015.09.016

2015

• Ou M, Hamilton TJ, Eom J, Lyall EM, Gallup J, Jiang A, Lee J, Close DA, Yun S, Brauner CJ. (2015) Responses of pink salmon to CO2-induced aquatic acidification. Nature Climate Change. 5, 950-955. doi:10.1038/nclimate2694

• Hamilton S, Hamilton TJ. (2015) Pedagogical tools to explore Cartesian mind-body dualism in the classroom: philosophical arguments and neuroscience illusions. Frontiers in Psychology. 6:1155. doi: 10.3389/fpsyg.2015.01155

2014

• Holcombe A, Schalomon M, Hamilton TJ. (2014) A Novel Method of Drug Administration to Multiple Zebrafish (Danio rerio) and the Quantification of Withdrawal. Journal of Visualized Experiments. (93), e51851, doi:10.3791/51851 (2014).

• Hamilton TJ, Paz-Yepes J, Morrison RA, Palenik B, Tresguerres M. (2014) Exposure to bloom-like concentrations of two marine Synechococcus cyanobacteria (strains CC9311 and CC9902) differentially alters fish behaviour. Conservation Physiology. 2 (1): cou020 doi: 10.1093/conphys/cou020

• Hamilton TJ, Holcombe A, Tresguerres M. (2014) CO2-induced ocean acidification increases anxiety in rockfish via alteration of GABAA receptor functioning. Proceedings of the Royal Society B. 2014 Jan 22;281(1775):20132509. doi: 10.1098/rspb.2013.2509

2013

• Hamilton TJ, Xiapelli S, Larkum M, Colmers WF. (2013) Modulation of Distal Calcium Electrogenesis by Neuropeptide Y1 Receptors Inhibits Neocortical Long-Term Depression. Journal of Neuroscience. 33(27): 11184-11193; doi: 10.1523/JNEUROSCI.5595-12.2013

• Holcombe A, Howorko A, Powell R, Schalomon M, Hamilton TJ. (2013) Decreased Scototaxis During Withdrawal After Chronic, but not Binge, Administration of Ethanol in Zebrafish. PLoS ONE  8(5): e63319. doi:10.1371/journal.pone.0063319

2010

• Hamilton TJ, Wheatley BM, Sinclair DB, Bachmann M, Larkum ME, Colmers WF. (2010) Dopamine modulates synaptic plasticity in dendrites of rat and human dentate granule cells. Proceedings of the National Academy of Sciences U S A. 107(42):18185-90. doi: 10.1073/pnas.1011558107

2005

• El Bahh B, Balosso S, Hamilton T, Herzog H, Beck-Sickinger AG, Sperk G, Gehlert DR, Vezzani A, Colmers WF. (2005) The antiepileptic actions of neuropeptide Y are mediated exclusively by the Y2 receptor. European Journal of Neuroscience. 22(6):1417-30.

Books/Chapters

• Khursigara, A. J., Roberts, A. P., Burggren, W., & Hamilton, T. J. (2024). Behavior and ecotoxicology. Encyclopedia of Fish Physiology, 706–720. https://doi.org/10.1016/b978-0-323-90801-6.00037-9

• Levinthal C, Hamilton TJ. Drugs, Behaviour and Modern Society. (2021).  Second Canadian Edition.  Pearson Education, Toronto, Canada.

• Heuer R, Hamilton TJ, Nilsson G. (2019). The physiology of behavioral impacts of high CO2. 10.1016/bs.fp.2019.08.002.  

  
  

• Hamilton, T. J. (2018). Object novelty and object location recognition memory in fish – recent advances. Handbook of Behavioral Neuroscience, 151–161. https://doi.org/10.1016/b978-0-12-812012-5.00009-4

  
  

• Dean R, Hamilton TJ. Testing of Object Recognition Memory in Adult Zebrafish. Zebrafish Neurobehaviour Protocols. (in press)

• Levinthal C, Hamilton TJ. Drugs, Behaviour and Modern Society. (2015).  First Canadian Edition.  Pearson Education, Toronto, Canada.

• Sperk G, Hamilton T, Colmers WF. Neuropeptide Y in the Dentate Gyrus. (2007) Chapter 17.  The Dentate Gyrus: A comprehensive guide to structure, function, and clinical implications. Elsevier. Vol 163.